The rationale for using intraoperative irradiation (IORT) is based on the realization that tolerable doses of eternal beam radiation are often insufficient to achieve control of locally advanced malignancies. In these instances, the IORT component of treatment becomes the optimal conformal technique of irradiation, since dose-limiting organs or structures can either be surgically displaced or protected by placement of lead shielding.

This fully revised and expanded second edition is of interest to those with intraoperative electron (IOERT) capabilities, high-dose-rate brachytherapy (HDR-IORT) capabilities, or both. Techniques, indications, and results are discussed by disease site. Each chapter is dual authored by a radiation oncologist and a surgeon, giving a balanced presentation of clinical scenarios. Issues of basic science and physics are also covered, and a notable chapter on normal tissue tolerance is included.

Intraoperative Irradiation: Techniques and Results, Second Edition is a superb compilation, providing essential cutting-edge knowledge. It is a foundation for physicians as IORT develops and becomes more widely available.

Part I. General Rationale and Historical Perspective

Ch 1 - Rationale and Historical Perspective of Intraoperative Irradiation Leonard L Gunderson, Felipe A Calvo, Christopher G Willett, and Louis B Harrison

Ch 2 - Radiobiology of Large Dose per Fraction Irradiation Paul Okunieff, Srinath Sundararaman, Su Metcalfe, and Yuhchyau Chen

Part II. Methods and Techniques of Treatment

Ch 3 - Intraoperative Electron-Beam Irradiation (IOERT): Physics and Techniques Peter Biggs, Christopher G. Willett, Harm Rutten, Mario Ciocca, Leonard L. Gunderson, and Felipe A. Calvo

Ch 4 - HDR-IORT: Physics and Techniques Eli E Furhang, Jussi K Sillanpaa, Kenneth Hu, and Louis B Harrison

Ch 5 - Electronic Brachytherapy/Low KV IORT: Physics and Techniques Uta Kraus-Tiefenbacher, Peter Biggs, Jayant Vaidya, and Dario Francescatti

Ch 6 - IORT with Electron Beam, High Dose Rate Brachytherapy or Low-KV/Electronic Brachytherapy: Methodological Comparisons Subir Nag, Christopher G. Willett, Leonard L. Gunderson, Louis B. Harrison, Felipe A. Calvo, and Peter Biggs

Part III. Normal Tissue Tolerance - IORT

Ch 7 - Normal Tissue Tolerance to IOERT, EBRT or Both: Animal Studies and Clinical Zeljko Vujaskovic, Christopher G Willett, Joel E Tepper, Timothy J Kinsella, and Leonard L Gunderson

Ch 8 - Central Nervous System Tumors David Ortiz de Urbina, Patrick Schueller, Normann Willich, Kintomo Takakura, Osami Kubo, and Felipe A. Calvo

Ch 9 - Head and Neck Cancer Kenneth S. Hu, Sue Yom, Michael J. Kaplan, Louis B. Harrison, and Rafael Martinez-Monge

Ch 10 - Breast Cancer Felix Sedlmayer, Jean-Bernard DuBois, Roland Reitsamer, Gerd Fastner, David Olilla, and Roberto Orecchia

Ch 11 - Lung Cancer Javier Aristu, Felipe A. Calvo, Marta Moreno, Rafael Martínez, Jesús Herreros, Raquel Ciérvide, Jean Bernard Dubois, and Scott Fisher

Ch 12 - Gastric Cancer Rafael Martinez-Monge, Miren Gaztañaga, Javier Álvarez-Cienfuegos, Robert C. Miller, and Felipe A. Calvo

Ch 13 - Pancreas Cancer Robert C. Miller, Vincenzo Valentini, Adyr Moss, Giuseppe R D'Agostino, Matthew D. Callister, Theodore Hong, Christopher G. Willett, and Leonard L. Gunderson

Ch 14 - Bile Duct and Gallbladder Cancer Takeshi Todoroki, Gernot M. Kaiser, Wolfgang Sauerwein, and Leonard L. Gunderson

Ch 15 - Primary Colorectal Cancer Nils D. Arvold, Theodore S. Hong, Christopher G. Willett, Paul C. Shellito, Michael G. Haddock, Harm Rutten, Vincenzo Valentini, Brian Czito, and Leonard L. Gunderson

Ch 16 - Recurrent Colorectal Cancer Michael G. Haddock, Heidi Nelson, Vincenzo Valentini, Leonard L. Gunderson, Christopher G. Willett, Harm Rutten, Felipe A Calvo, Lou Harrison, Warren Enker, and JL Garcia-Sabrido

Ch 17 - Retroperitoneal Sarcomas Brian Czito,  John Donohue, Christopher Willett, Doug Tyler, Ivy Petersen, Robert Krempien, Kenneth Hu, Felipe Calvo, Matthew Callister, Kaled Alektiar, Michael Eble,            and Ana Alvarez

Ch 18 - Extremity and Trunk Soft Tissue Sarcomas Ivy A Petersen, Robert Krempien, Christopher Beauchamp, Michael Eble, Felipe Calvo, Ignacio Azinovic, Matthew A Callister, and Ana Alvarez

Ch 19 - Bone Sarcomas Felipe A. Calvo, Luis Sierrasesumaga, Ana Patiño, Carmen González, Manuel González, Carlos Ferrer, Norman Willich, and José Cañadell

Ch 20 - Gynecologic Malignancies Kaled M. Alektiar, Michael G. Haddock, Dennis Chi, Felipe A. Calvo, and Ivy A. Petersen

Ch 21 - Genitourinary Cancer Marco Krengli, Felipe A. Calvo, Carlo Terrone, Michael Haddock, Jean-Michel Hannoun-Levi, Juliette Thariat, Jean-Pierre Gerard, and Roberto Orecchia

Ch 22 - Pediatric Malignancies Nadia N. Issa Laack, Paula J. Schomberg, Suzanne Wolden, and  Jesus Vazquez

Part V. Conclusions and Future Possibilities

Ch 23 - Conclusions and Future Possibilities - IORT Leonard L Gunderson, Christopher G Willett, Felipe A Calvo, and Louis B Harrison