Of Sin and Soul follows the travails of a young American woman, Chloe Ettagio, who leaves her home and family behind and escapes her loveless marriage by emigrating to the west coast of Ireland.

She embarks on a torrid but disastrous sexual affair when settled there, and this affair reshapes the rest of her life. We learn how a singular life event can change our destiny so dramatically, and of the family secrets and the community's efforts to protect those secrets.

In Of Sin and Soul by Liam Murphy, we encounter a clash of belief systems and cultures. We look behind the outer facade of Chloe's family and community bonds that prevent her from achieving all the fullness of her being.