Changing demographics and evolving technology continuously affect maternal-fetal medicine Increasing maternal age and weight during pregnancy, higher rates of pregnancies conceived by artificial reproductive technologies and growing numbers of cesarean deliveries have led to a rise in the incidence of complicated pregnancies. The options have also increased for monitoring maternal and fetal health throughout a pregnancy, and identifying and managing risk earlier. For the maternal-fetal physician, constant vigilance throughout a pregnancy remains essential. But continuous change makes this an increasing challenge. Queenan's Management of High-Risk Pregnancy covers the full spectrum of perinatal care. It guides you through the tough and complex decisions needed to protect the health of both your fetal and the maternal patients. New material in the 6th edition covers contemporary issues such as: * Iron-deficient anemia * Malaria * Pregnancy in the disabled woman * Placenta accreta * Induction of labor * Operative vaginal delivery * Patient safety in labor and delivery The stellar cast of expert authors provide evidence, algorithms, case studies and potential outcome measures to ensure that Queenan's Management of High-Risk Pregnancy continues to set the bar for maternal-fetal practice. Titles of Related Interest Stillbirth Edited by Catherine Y. Spong ISBN 978-1-4443-3706-8 The Placenta: From Development to Disease Edited by Helen Kay, D. Michael Nelson and Yuping Wang ISBN 978-1-4443-3366-4 Pregnancy in the Obese Woman: Clinical Management Edited by Deborah E. Conway ISBN 978-1-4051-9648-2

Edited by John T. Queenan, MD, Professor and Chair Emeritus, Department of Obstetrics & Gynecology, Georgetown University School of Medicine , Washington, DC, USA Catherine Y. Spong, MD, Bethesda, MD, USA Charles J. Lockwood, MD, Anita O'Keeffe Young Professor & Chair, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA

List of Contributors, vii Foreword, xi Preface, xii Acknowledgments, xii List of Abbreviations, xiii Part 1 Factors of High-Risk Pregnancy 1 Overview of High-Risk Pregnancy, 1 John T. Queenan, Catherine Y. Spong, and Charles J. Lockwood 2 Maternal Nutrition, 4 Edward R. Newton 3 Alcohol and Substance Abuse, 23 William F. Rayburn 4 Environmental Agents and Reproductive Risk, 32 Laura Goetzl Part 2 Genetics 5 Genetic Screening for Mendelian Disorders, 41 Deborah A. Driscoll 6 Screening for Congenital Heart Disease, 47 Lynn L. Simpson 7 First- and Second-Trimester Screening for Fetal Aneuploidy and Neural Tube Defects, 55 Julia Unterscheider and Fergal D. Malone Part 3 Monitoring: Biochemical and Biophysical 8 Sonographic Dating and Standard Fetal Biometry, 63 Eliza Berkley and Alfred Abuhamad 9 Fetal Lung Maturity, 75 Alessandro Ghidini and Sarah H. Poggi 10 Antepartum Fetal Monitoring, 79 Brian L. Shaffer and Julian T. Parer 11 Interpreting Intrapartum Fetal Heart Tracings, 89 Michael Nageotte Part 4 Maternal Disease 12 Sickle Cell Anemia, 93 Scott Roberts 13 Anemia, 98 Alessandro Ghidini 14 Thrombocytopenia, 102 Robert M. Silver 15 Inherited and Acquired Thrombophilias, 108 Michael J. Paidas 16 Thromboembolic Disorders, 121 Christian M. Pettker and Charles J. Lockwood 17 Cardiac Disease, 131 Stephanie R. Martin, Alexandria J. Hill, and Michael R. Foley 18 Renal Disease, 151 David C. Jones 19 Pregnancy in Transplant Patients, 160 James R. Scott 20 Gestational Diabetes Mellitus, 168 Deborah L. Conway 21 Diabetes Mellitus, 174 George Saade 22 Hypothyroidism and Hyperthyroidism, 178 Brian Casey 23 Asthma, 183 Michael Schatz 24 Epilepsy, 193 Autumn M. Klein and Page B. Pennell 25 Chronic Hypertension, 204 Heather A. Bankowski and Dinesh M. Shah 26 Systemic Lupus Erythematosus, 209 Christina S. Han and Edmund F. Funai 27 Perinatal Infections, 218 Jeanne S. Sheffield 28 Malaria, 231 Richard M.K. Adanu 29 Group B Streptococcal Infection, 234 Ronald S. Gibbs 30 Hepatitis, 238 Patrick Duff 31 HIV Infection, 243 Howard L. Minkoff 32 Pregnancy in Women with Physical Disabilities, 253 Caroline C. Signore Part 5 Obstetric Complications 33 Recurrent Spontaneous Abortion, 260 Charles J. Lockwood 34 Cervical Insufficiency, 271 John Owen 35 Gestational Hypertension, Preeclampsia, and Eclampsia, 280 Labib M. Ghulmiyyah and Baha M. Sibai 36 Postpartum Hemorrhage, 289 Michael A. Belfort 37 Emergency Care, 301 Garrett K. Lam and Michael R. Foley 38 Rh and Other Blood Group Alloimmunizations, 307 Kenneth J. Moise Jr 39 Multiple Gestations, 314 Karin E. Fuchs and Mary E. D'Alton 40 Polyhydramnios and Oligohydramnios, 327 Ron Beloosesky and Michael G. Ross 41 Prevention of Preterm Birth, 337 Paul J. Meis 42 Pathogenesis and Prediction of Preterm Delivery, 346 Catalin S. Buhimschi and Charles J. Lockwood 43 Preterm Premature Rupture of Membranes, 364 Brian M. Mercer 44 Management of Preterm Labor, 374 Vincenzo Berghella 45 Placenta Previa and Related Placental Disorders, 382 Yinka Oyelese Part 6 Complications of Labor and Delivery 46 Prolonged Pregnancy, 391 Teresa Marino and Errol R. Norwitz 47 Induction of Labor, 399 Nicole M. Petrossi and Deborah A. Wing 48 Cesarean Delivery, 406 Michael W. Varner 49 Vaginal Birth After Cesarean Delivery, 414 Mark B. Landon 50 Breech Delivery, 424 Edward R. Yeomans and Larry C. Gilstrap 51 Operative Vaginal Delivery, 429 Edward R. Yeomans 52 Obstetric Analgesia and Anesthesia, 43 Gilbert J. Grant 53 Patient Safety, 439 Christian M. Pettker 54 Neonatal Encephalopathy and Cerebral Palsy, 445 Maged M. Costantine, Mary E. D'Alton, and Gary D.V. Hankins Part 7 Procedures 55 Genetic Amniocentesis and Chorionic Villus Sampling, 453 Ronald J. Wapner 56 Fetal Surgery, 464 Robert H. Ball and Hanmin Lee Index, 475 The color plate section can be found facing p. 192