Stem Cells: An Alternative Therapy for COVID-19 and Cytokine Storm provides mechanistic insights into the role of stem cells to combat COVID-19 outbreak and other pathologies where cytokines storm is the cause of concern for e.g., radiation exposure, multiple organ failure and sepsis. There has been an increase in number of cases of new diseases in the last decade, including mucormycosis, Zika virus, H1N1 influenza virus, among others. These diseases can be characterized by the induction of cytokine storm, which is mainly responsible for morbidity and mortality.
Stem cell therapy has emerged as a potential treatment for viral diseases, including, but not limited to, COVID-19. Interestingly, clinical trials in patients with COVID-19 complications depicted faster recovery in patients post mesenchymal stem cells therapy owing to the decreased cytokines levels, anti-viral effects and regeneration of the infected tissue.
Stem Cells: An Alternative Therapy for COVID-19 and Cytokine Storm provides mechanistic insights into the role of stem cells to combat COVID-19 outbreak and other pathologies where cytokines storm is the cause of concern for e.g., radiation exposure, multiple organ failure and sepsis. There has been an increase in number of cases of new diseases in the last decade, including mucormycosis, Zika virus, H1N1 influenza virus, among others. These diseases can be characterized by the induction of cytokine storm, which is mainly responsible for morbidity and mortality.
Stem cell therapy has emerged as a potential treatment for viral diseases, including, but not limited to, COVID-19. Interestingly, clinical trials in patients with COVID-19 complications depicted faster recovery in patients post mesenchymal stem cells therapy owing to the decreased cytokines levels, anti-viral effects and regeneration of the infected tissue.
Targets of SARS-CoV-2: Therapeutic Implications for COVID-19
COVID-19 Biology: Cytokine Storms and Their Implications
Comparative Clinical Investigation of Blood Profiling in COVID-19
Patients
SARS-CoV-2 Associated Complications
COVID-19 Diagnostic Approaches and Modern Mesenchymal Stem
Cell-based Treatment
Modulation of Pentose Phosphate Pathway Augments the Efficacy of
2-deoxy-D-glucose in COVID-19 Management
Therapeutic Landscape of SARS-CoV-2
Pharmacotherapeutics for Cytokine Storm in COVID-19
Clinical Investigation of COVID-19 Prevention and Treatment
Potential Therapeutic Landscape of COVID-19: Molecular Targets,
Repurposed Drugs, and Nano- and Cell-based Intervention
Medical Care for SARS-CoV-2
Therapeutic Approaches for Opportunistic Infection
Post-COVID-19
Focusing on the Cytokine Storm in the Battle Against COVID-19: The
Rising Role of Mesenchymal-derived Stem Cells
Cytokine Storm in COVID-19 and Other Diseases: Emerging Therapeutic
Interventions
Stem Cells as Therapeutics and Their Implications in Cytokine Storm
in COVID-19
Visualizing Chemical Functionality and Structural Insights into
SARS-CoV-2 Proteins
Mesenchymal Stromal Cells and Pleiotropic Therapeutic Advantages in
COVID-19 Management
Mesenchymal Stem Cells - Role in Tuberculosis Pathogenesis and
Persistence
Radiosensitivity of Cancer Stem Cells Holds Promise for the Outcome
in Radiotherapy and COVID-19 Infections
Immunomodulatory Therapeutic Potential of Mesenchymal Stem Cells in
COVID-19 Pathogenesis
Clinical Limitations of Stem Cell Therapy
Clinical Limitations in Stem Cell Therapy
Stem Cell Based Products and the Regulatory Hurdle Race
Implications of Stem Cell Therapy on the Socio-Scientific Community
Dr. Yogesh Kumar Verma, MNABS, is working as Scientist ‘E’ in
INMAS, DRDO, Delhi, India. He completed his M.Sc. and Ph.D. in
Biomedical Science from Delhi University, India. He also has
another M.Sc. degree in Bioinformatics from Punjab Technical
University, India. In year 2009, he joined INMAS, DRDO, Delhi,
India, as Scientist ‘C’. He is presently working in the area of
stem cell research, microencapsulation, regenerative medicine,
tissue engineering and omics data mining and analysis for
repairing/ regenerating various types of tissues for Defence
application. He has been awarded with many fellowships, project
grants, and has published many articles including manuscripts,
patents, book chapters etc. Dr. Neeraj Kumar Satija PhD is working
as a Senior Scientist at CSIR-Indian Institute of Toxicology
Research, Lucknow, India. He completed his B.Tech and M.Tech in
Biotechnology from School of Biotechnology, Guru Gobind Singh
Indraprastha University, Delhi, India. Thereafter, he undertook
doctoral studies at Institute of Nuclear Medicine and Allied
Sciences, Delhi, India, elucidating role of Wnt signaling and its
downstream target genes in mediating osteoblast differentiation of
human mesenchymal stem cells, and identified lithium as a priming
agent for enhancing osteogenic differentiation potential of
mesenchymal stem cells. In 2014, he joined CSIR-Indian Institute of
Toxicology Research, Lucknow, India, as a Scientist. His group is
working in varied disciples such as stem cell toxicology, embryonic
stem cell differentiation, leukemia chemoresistance and wound
healing. He has mentored a number of graduate/post-graduate
students and is guiding Ph.D. scholars. Dr. Pawan Kumar Raghav is
currently a researcher the School of Medicine, Department of
Surgery, University of California, San Francisco. He is developing
novel approaches for investigating immune/inflammatory mechanisms
of allograft injury and discovering new biomarkers and therapeutics
in solid organ and bone marrow transplantation. He is the recipient
of several awards and honors, including the ICMR Travel Award to
deliver an oral talk in 11th world congress & expo on cell & stem
cell research in Orlando, FL; Research Excellence Award from the
Institute of Scholars, best Research Award from Science Father, and
was invitated to present the research proposal at BioMed X GmbH,
Germany. He has published more than 40 publications, including
international research articles, book chapters, books, and
intellectual property rights for patents. He is also reviewer and
editor of special collections for several international journals
and books. Nishant Tyagi MSc is an Indian-born Senior Research
Fellow, presently working at Stem Cells and Gene Therapy Research
Group, Institute of Nuclear Medicine and Allied Sciences under
Defence Research & Development Organisation, India. He graduated
from Kirorimal College, University of Delhi, India, and completed
his master’s degree from Jamia Hamdard, New Delhi, India, in
Biotechnology. He is a recipient of several awards and fellowships
like NET-JRF, IIT GATE, and DRDO fellowship. He joined the Stem
Cells and Gene Therapy Research Group in 2018 and has maintained a
proactive approach to the research project and input ideas along
with solid knowledge and research experience in biomaterial
science. He is currently working under the guidance of Dr. Yogesh
Kumar Verma, Senior Scientist, INMAS, in multiple defense-funded
projects and has published several publications and filed many
patents. Subodh Kumar MSc is an Indian-born Senior Research Fellow,
currently working in Stem Cells and Gene Therapy Research Group,
Institute of Nuclear Medicine and Allied Sciences, DRDO, in the
defence funded project. Over the past two and half years he has
worked in many research projects in the AIIMS and INMAS. He has
earned his B.Sc. degree from Hansraj College, Delhi University and
M.Sc. degree (Medical Biotechnology) from Maharishi Dayanand
University, Rohtak, Haryana, sponsored by Department of
Biotechnology, Government of India (PG research fellow).
He has also qualified, GATE and CSIR JRF fellowship conducted by
IITs and CSIR on behalf of Government of India respectively. He
joined PhD under the supervision of senior scientist Dr. Yogesh
Kumar (Sc. E), INMAS, DRDO.
Subodh Kumar has published many research papers and book
chapters.
He is correctly putting his intellect for the research community
through his writing and brain-storming scientific ideas.
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