Under a powerful Mayan curse, snakes are hatched inside a young woman. Her only chance for survival is a powerful shaman who lives across the Mexican border. With only hours to live, she smuggles aboard a train headed for Los Angeles under the watchful eye of her husband. With border patrol on the hunt and time running out, he will let nothing stop the train from arriving in Los Angeles. Unbeknownst to the passengers aboard, they are now trapped, and the snakes want to get out.