The purpose of this book is to show how mechanistic principles can be applied both to acquiring a knowledge of organic synthetic processes and to planning the construction of organic compounds. It is designed for those who have had no more than a brief intoduction to organic chemistry amd who require a broad introduction to the subject. The book is in two parts. In part one, reaction mechanism is set in its wider context of the basic principles and concepts that underlie chemical reactions - chemical thermodynamcis, structural theory, theories of reaction kinetics, mechanism itself and stereochemistry. In part two, these principles and concepts are applied to the formation of particular types of bonds, groupings and compounds: for example, how small molecules can be built on to give larger ones by the construction of new carbon-carbon bonds, or how one functional group can be transformed into another. The final chapter in part two describes the planning and detailed execution of the multi-step synthesis of several complex naturally occurring compounds.
There have been numerous important developments since the second edition of this book was published 15 years ago, and every chapter has been brought up to date to include them. Among the more notable are: the stereochemical control of reactions, reflecting the need to synthesize efficiently compounds with several asymmetric centres; the use of organotransition-metal reagents, leading to a new chapter; the exploitation of lithium dilsopropylamide (LDA) as a base in the formation of new C-C bonds; free-radical reactions for the synthesis of C-C bonds; uses of organosilicon compounds; and subtle new protective and condensing reagents in polypeptide synthesis. An ELBS/LPBB edition is available
The purpose of this book is to show how mechanistic principles can be applied both to acquiring a knowledge of organic synthetic processes and to planning the construction of organic compounds. It is designed for those who have had no more than a brief intoduction to organic chemistry amd who require a broad introduction to the subject. The book is in two parts. In part one, reaction mechanism is set in its wider context of the basic principles and concepts that underlie chemical reactions - chemical thermodynamcis, structural theory, theories of reaction kinetics, mechanism itself and stereochemistry. In part two, these principles and concepts are applied to the formation of particular types of bonds, groupings and compounds: for example, how small molecules can be built on to give larger ones by the construction of new carbon-carbon bonds, or how one functional group can be transformed into another. The final chapter in part two describes the planning and detailed execution of the multi-step synthesis of several complex naturally occurring compounds.
There have been numerous important developments since the second edition of this book was published 15 years ago, and every chapter has been brought up to date to include them. Among the more notable are: the stereochemical control of reactions, reflecting the need to synthesize efficiently compounds with several asymmetric centres; the use of organotransition-metal reagents, leading to a new chapter; the exploitation of lithium dilsopropylamide (LDA) as a base in the formation of new C-C bonds; free-radical reactions for the synthesis of C-C bonds; uses of organosilicon compounds; and subtle new protective and condensing reagents in polypeptide synthesis. An ELBS/LPBB edition is available
Part One: Chemical thermodynamics. Molecular structure. Chemical kinetics. Mechanism. Stereochemistry. Part Two: Formation of carbon-carbo bonds: organometallic reagents. Formation of aliphatic carbon-carbon bonds: base-catalyzed. Formation of aliphatic carbon-carbon bonds: acid catalyzed. Pericyclic reactiions. Formation of aliphatic carbon-nitrogen bonds. Electrophilic aromatic substitution. Nucleophylic aromatic substitution. Aromatic diazonium salts. Molecular rearrangements. Reagents containing phosphorus, sulphur or boron. Photochemical reactions. Free-radical reactions. Organotransition metal reagents. Oxidation. Reduction. Organotransition metal regents. The synthesis of five and six-membered heterocyclic compounds. The synthesis of some naturally occurring compounds. Index.
Springer Book Archives
Springer Book Archives
It is an absolute 'must' for the reading list of all teachers of organic chemistry and I am sure it will become included in the reading lists of their students. - Nature; A very good book which is likely to become extremely popular. Organic chemists at all levels of training and experience will find it to be a worthwhile acquisition. - Chemistry & Industry; This is a very good book and the treatment of organic chemistry is much wider than the title indicates. - Endeavour; I recommend it as a general text for students...the authors have produced a clear, modern text which covers an enormous amount of chemistry... - Education in Chemistry; Since its first publication in 1968, this book has become virtually th de facto textbook for organic synthesis in UK universities...This third edition brings the content up to date with recent developments in organic synthesis, and will ensure a continued use as a standard undergraduate text. - Chemistry in Britain; This third edition brings the content up to date with recent developments in organic synthesis, and will ensure its continued use as a standard undergraduate text. |oChemistry in Britain |dJune 1994
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