1. Introduction and Overview, David G. Lichter and Jeffrey L.
Cummings
2. A Revised Neuroanatomy of Frontal-Subcortical Circuits, Frank A.
Middleton and Peter L. Strick
3. Neurochemistry of Frontal-Subcortical Circuits, Yuri L.
Bronstein and Jeffrey L. Cummings
4. Neurophysiology of Frontal-Subcortical Loops, James C. Houk
5. Cognitive Abilities Mediated by Frontal-Subcortical Circuits,
David P. Salmon, William P. Heindel, and Joanne M. Hamilton
6. Personality and Behavioral Changes with Frontal-Subcortical
Dysfunction, Irene Litvan
7. The Disinhibition Syndrome and Frontal-Subcortical Circuits,
Sergio E. Starkstein and Janus Kremer
8. Depression and Frontal-Subcortical Circuits: Focus on
Prefrontal-Limbic Interactions, Helen Mayberg
9. Cortical-Subcortical Systems in the Mediation of
Obsessive-Compulsive Disorder: Modeling the Brain's Mediation of a
Classic Neurosis, Lewis R. Baxter Jr., Edward C. Clark, Mohammed
Iqbal, and Robert F. Ackermann
10. Addictions and Frontal-Subcortical Circuits, Horacio A. Capote,
Leayn Flaherty, and David G. Lichter
11. Movement Disorders and Frontal-Subcortical Circuits, David G.
Lichter
12. Frontal-Subcortical Circuits: A Functional Developmental
Approach, Marcia J. Slattery, Majorie A. Garvey, and Susan E.
Swedo
13. Attention-Deficit/Hyperactivity Disorder as a
Frontal/Subcortical Disorder, Kytja K. S. Voeller
14. The Role of Frontal-Subcortical Circuits in the Pathophysiology
of Schizophrenia, Anthony R. West and Anthony A. Grace
15. Neuropharmacology of Frontal-Subcortical Circuits, Yuri L.
Bronstein and Jeffrey L. Cummings
16. Psychosurgery of Frontal-Subcortical Circuits, Seth M.
Weingarten and Jeffrey L. Cummings
David G. Lichter, M.D. , ChB, FRACP, Dept. of Neurology, School
of Medicine and Biomedical Sciences, State University of New York
at Buffalo.
Jeffrey L. Cummings, M.D., Depts. of Neurology and of Psychiatry
and Biobehavioral Sciences, School of Medicine, University of
California, Los Angeles.
This elegant text addresses what is perhaps the most important
conceptual development in late 20th-century neuropsychiatry. There
is now common agreement that brain-behavior relationships are
predictably tied to the organization of discrete yet interconnected
neural circuits that link the frontal and limbic cortices with the
basal ganglia. This volume explores the role of these 'loops' in
the primary manifestations of specific lesion-based neurologic
syndromes and then, by extension, in the expression of virtually
every major class of neuropsychiatric disorder. Specific
dysfunction of intricate neurochemical and synaptic subterritories
within the frontal-subcortical circuits must account for conditions
as categorically distinct as depression, schizophrenia, OCD,
substance abuse, ADHD, mania, and Tourette syndrome. Extrapolating
from the signature syndromes of frontal-subcortical circuit
dysfunction to the complexities of such neuropsychiatric states
will require a much finer parsing of these circuits. This text can
serve as a valuable primer for this process--a road map to the
circuit 'interstates' as we move ahead to explore the neuronal side
streets of the psyche. --Neal R. Swerdlow, MD, PhD, Department of
Psychiatry, School of Medicine, University of California, San
Diego
The arrival of this landmark volume could not be more timely. There
is no other text available that devotes itself completely to the
topic. Contributors cogently argue that a spectrum of neurological
and psychiatric disorders should be placed within the context of a
systems-level dysfunction. Lichter and Cummings have done a
wonderful job of recruiting the leading proponents of the systems
approach, and have masterfully integrated the chapters to reduce
redundancy and enhance the integration of topics. This book is
recommended for researchers in neuropsychiatry, behavioral
neurology, and cognitive neuroscience, as well as practitioners in
the clinical neurosciences who are yearning for a focused and
intelligent alternative to simple localizationist views of
behavior.--Jordan Grafman, PhD, Chief, Cognitive Neuroscience
Section, National Institute of Neurological Disorders and
Stroke
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