Table of Contents

Acyclovir - mechanism of antiviral action and potentiation by ribonucleotide reductase inhibitors; rational approaches to osteoporosis therapy; molecular asymmetry and its pharmacological consequences; blood-brain barrier - transport studies in isolated brain capillaries and in cultured brain endothelial cells; protein kinase inhibitors - probes for the functions of protein phosphorylation; renin inhibitors; the capacitative model for receptor-activated calcium entry; calcium channel antagonists in the prevention of neurotoxicity; new directions in the delivery of drugs and other substances to the central nervous system; hormonal regulation of cytochrome P-450 gene expression.