I. Introduction and Methodology Quantivative PCR: an
introduction Signal Amplification Methods in Molecular Diagnostics
The Lab-on-a-Chip Approach for Molecular Diagnostics Nucleic
Extraction and Amplification General Procedures
II. Quality Assurance, Regulatory, and
Ethical Issues Billing and Reimbursement for Molecular
Diagnostics Molecular Pathology and Infectious Diseases Ethical
Considerations in Molecular Diagnostics Quality Control, Assurance,
Identification and Standards III. Genetic
Disease Molecular Testing for Cystic Fibrosis and
CFTR-Related Conditions Carrier Testing for Neurogenetic Diseases
Hemochromatosis Standards and Recommendations for Molecular
Diagnostic Testing for Huntington Disease, the Autosomal Dominant
Spinocerebellar Ataxias, and Friedreich Ataxia IV.
Cancer The Role of Micro-RNAs in Cancer Molecular
Diagnostics in the Evaluation of Cancer: Modern Concepts and
Overview Gene Expression Analysis for Tumor Profiling GEA for TP
Molecular Diagnostics of Hematopoetic Malignancies V.
Infectious Diseases Viruses Hepatic B and C Viruses
Molecular Diagnosis of Cytomegalovirus Molecular Detection of
Multiple Respiratory Viruses
Bacteria Molecular Methods for Identification and Characterization
of Acinetobacter species Molecular Detection and Surveillance of
Healthcare-Associated Infections Molecular Detection Of Group B
Streptococcus Role of Molecular Techniques in the Epidemiologic
Investigation Of Hospital-Acquired Infections Human Papilloma Virus
and its Role in Cervical Carcinoma VI. Specialized
Applications of Molecular Testing Molecular HLA Typing
Methods Used in Clinical Laboratories Identification through DNA
analysis in criminal and family relatedness investigations.
VII. Pharmacogenetics Overview of Pharmacogenomics and
Applications for the Modern Clinical Laboratory
UDP-Glucuronosyltransferase 1A1 and the Glucuronidation in Oncology
Applications and Hyperbilirubinemia Pharmacogenetics of P-450
Enzymes Pharmacogenomics of Thiopurine Methyl Transferase (TPMT):
Importance in Monitoring of Mercaptopurine/Azathioprine Therapy
Wayne W. Grody, M.D., Ph.D. is a Professor in the Departments of Pathology & Laboratory Medicine, Pediatrics, and Human Genetics at the UCLA School of Medicine. He is the director of the Diagnostic Molecular Pathology Laboratory within the UCLA Medical Center, and is also an attending physician in the Department of Pediatrics, specializing in the care of patients with or at risk for genetic disorders. He has been one of the primary developers of quality assurance and ethical guidelines for DNA-based genetic testing for a number of governmental and professional agencies including the FDA, AMA, CAP, ACMG, ASHG, NCCLS, CDC, NIH-DOE Human Genome Project (ELSI program), and PSRGN. He served as a member of the NIH-DOE Task Force on Genetic Testing, and was the working group chair for development of national guidelines for cystic fibrosis and factor V-Leiden mutation screening. Most recently, he was appointed chair of an Advisory Committee on Genomic Medicine for the entire VA healthcare system. He did his undergraduate work at Johns Hopkins University, received his M.D. and Ph.D. at Baylor College of Medicine, and completed residency and fellowship training at UCLA. He is double board-certified by the American Board of Pathology (Anatomic and Clinical Pathology, Molecular Genetic Pathology) and the American Board of Medical Genetics (Clinical Genetics, Molecular Genetics, and Biochemical Genetics).
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