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This volume of Methods in Enzymology is the companion to volume 502 and looks at Protein Engineering for Therapeutics

Table of Contents

Part III: Peptides
1. Stapled Peptides for Intracellular Drug Targets
2. Mapping of vascular zip codes by phage display
3. Engineering cyclic peptide toxins
4. Peptide Discovery using Bacterial Display and Flow Cytometry

Part V: Scaffolds
5. Designed Ankyrin Repeat Proteins (DARPins): From research to therapy
6. Target-binding proteins based on the tenth human fibronectin type III domain (10Fn3)
7. Anticalins: small engineered binding proteins based on the lipocalin scaffold
8. T Cell Receptor Engineering
9. Engineering Knottins as Novel Binding Agents

Part VI: Pharmacokinetics
10. Practical Theoretic Guidance for the Design of Tumor Targeting Agents
11. Re-Engineering Biopharmaceuticals for Targeted Delivery Across the Blood-Brain Barrier
12. Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells