Table of Contents

TABLE OF CONTENTS
Contributors
Section 1 - What Are We Studying and Why?

1. The Functional Anatomy of White Matter: From Postmortem Dissections to In Vivo Virtual Tractography - Marco Catani

2. Neurobiology of White Matter Disorders - Christopher M. Filley

3. Invasive Methods for Tracing White Matter Architecture - Hubertus Axer

Section 2 - The Basics of Diffusion MRI

4. The Physics of Diffusion - Paul T. Callaghan

5. Magnetic Resonance Diffusion Imaging: Introduction and Concepts - Denis Le Bihan

6. Anisoptropic Diffusion: From the Apparent Diffusion Coefficient to the Apparent Diffusion Tensor - Peter J. Basser and Evren Özarslan

7. What Makes Diffusion Anisotropic in the Nervous System? - Christian Beaulieu

8. Biophysics of Diffusion in Cells - Joseph J.H. Ackerman and Jeffrey J. Neil

9. Extracting Geometric Properties of White Matter with q-Space Diffusion MRI (QSI) - Yaniv Assaf and Yoram Cohen

10. The Cumulant Expansion: An Overarching Mathematical Framework For Understanding Diffusion NMR - Valerij G. Kiselev

Section 3 - Experimental Aspects of Diffusion MRI

11. Hardware Considerations for Diffusion MRI - Nirbhay N. Yadav, Tim Stait-Gardner, and William S. Price

12. EPI-Based Pulse Sequences for Diffusion Tensor MRI - Stefan T. Skare and Roland Bammer

13. Non-EPI Pulse Sequences for Diffusion MRI - James G. Pipe

14. Phase Errors in Diffusion-Weighted Imaging - Roland Bammer, Samantha J. Holdsworth, Murat Aksoy, and Stefan T. Skare

15. Optimal Approaches to Diffusion MRI Acquisition - Derek K. Jones

16. Least Squares Approaches to Diffusion Tensor Estimation - Cheng Guan Koay

17. Image Distortion and Its Correction in Diffusion MRI - Jesper J.L. Andersson and Stefan T. Skare

18. Artifacts in Diffusion MRI - Carlo Pierpaoli

19. Quality Assurance for Diffusion MRI - Nicholas G. Dowell and Paul S. Tofts

20. Statistical Issues in Diffusion Tensor MRI - Sinisa Pajevic

21. Visualization of Diffusion MRI Data - Alexander Leemans

Section 4 - Fiber Tracking

22. Deterministic White Matter Tractography - Andrew L. Alexander

23. Probabilistic White Matter Tractography - Geoff J.M. Parker

24. Connectivity-Based Parcellation of Gray Matter - Timothy Behrens, Johannes Klein, Saad Jbabdi, and Heidi Johansen-Berg

25. Diffusion Tensor Microimaging and its Applications - Jiangyang Zhang, Hao Huang, Manisha Aggarwal, and Susumu Mori

26. Anatomical Validation of DTI and Tractography - I. Nigel C. Lawes and Christopher A. Clark

Section 5 - Crossing Fibers

27. Mathematics of Crossing Fibers - Daniel Alexander and Kiran Seunarine

28. The Biophysics of Crossing Fibers - Jacques-Donald Tournier

Section 6 - Diffusion MRI of Brain Disorders

29. Strategies for Patient-Control Comparison of Diffusion MR Data - Mara Cercignani

30. DTI in Brain Development - Petra Hüppi

31. Diffusion in Acute Stroke - Ona Wu, Lauren Nentwich, Aurauma Chutinet, and Ahmad Bayrlee

32. Diffusion in Chronic Stroke and Small Vessel Disease - Michael O'Sullivan

33. Diffusion Imaging in Brain Tumors - Aaron S. Field

34. Diffusion Tensor MRI in Multiple Sclerosis - Massimo Filippi and Maria A. Rocca

35. Diffusion MRI in Epilepsy - Khalid Hamandi and Robert Powell

36. DTI and Tractography in Neurosurgical Planning - Christopher A. Clark and Tiernan Byrnes

37. Diffusion MRI in Psychiatric Disorders - Tonya White and Kelvin O. Lim

38. Diffusion Tensor Imaging in Aging and Age-Related Neurodegenerative Disorders - Edith V. Sullivan and Adolf Pfefferbaum

Section 7 - Diffusion MRI Beyond White Matter

39. Diffusion Imaging in Gray Matter - Helen D'Arceuil and Alex de Crespigny

40. Diffusion Imaging in the Optic Nerve, Spinal Cord, and Peripheral Nerve - Claudia Wheeler-Kingshott and Olga Ciccarelli

41. Diffusion Imaging in Muscle - Gustav J. Strijkers, Maarten R. Drost, and Klaas Nicolay

42. Insights into Diffusion Tensor Imaging from Animal Models of White Matter Pathology - Matthew D. Budde and Sheng-Kwei Song

Section 8 - How It All Started-Personal Perspectives from the Pioneers

43. Reminiscences about the Development of Pulsed Field Gradient Spin Echo NMR (PFGSE-NMR) - Ed O. Stejskal and John E. Tanner

44. Diffusion, Diffraction, and Microimaging - Paul T. Callaghan

45. Diffusion MRI: Conception, Birth, and Adolescence - Denis Le Bihan

46. DWI in Cerebral Ischemia: The Early Days - Michael E. Moseley

47. Invention and Development of Diffusion Tensor MRI (DT-MRI or DTI) at the NIH - Peter J. Basser

Index

About the Author

Professor and Director of MRI, Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff, Wales, UK.

Reviews

"This is a truly comprehensive compilation of the science and application of these techniques in the study of brain. The book is organized into 8 sections from the physics and basics to the use of these approaches in the characterization of neurological and psychiatric disorders. There are sections on experimental considerations, analysis including fiber tracking and crossing fibers. There is also a section entitled 'Diffusion MRI Beyond White Matter' attesting to the great potential and future application of diffusion imaging and a final section that outlines the history of its evolution and personal perspectives of several pioneers. Although the book has almost 50 chapters between its covers there is little, if any, redundancy. This book is a tour de force on the topic of diffusion MRI and a must read for any student or investigator interested in this exciting and important imaging field."
--Arthur W. Toga, PhD, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA

"This remarkable compendium of 47 chapters written by the world experts provides the most comprehensive and the most detailed description of this novel and sophisticated method. There is something of interest for everyone: from theory to hardware; from physics to biology; from animal to human internal anatomy; from general medicine to specialized diseases; and, most importantly, from brain architecture underlying normal behavior to abnormalities in neurology and psychiatry, which have benefited enormously by the introduction of this method. It may sound as a cliche that it is a must, not only for imagers, specialists and researchers, but also for general practitioners, if they need and want to be informed."
- Pasko Rakic, MD, PhD, Duberg Professor of Neurobiology and Neurology, Chairman, Department of Neurobiology, Director, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT and Editor-in-Chief of Cerebral Cortex

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