Table of Contents

TABLE OF CONTENTS
INTRODUCTION
PART I - FUNDAMENTALS
Chapter 1. Science
Science does not exist
Reductionism, its advantages and limits
On theories and Theories
Evolution and Life
Chapter 2. Biomedical Research
Biochemistry and cell biology lite
How we classify life
Animal models and biomedical research
Basic or fundamental research?
PART II - THE SCIENCE OF THE BRAIN
Chapter 3. An introduction to neuroscience
Neuroscience or neurobiology?
Neurons
The Spaniard and the Italian
Excitable cells and electrophysiology
Synapses and chemical neurotransmission
Is a nervous system absolutely necessary for survival?
Plant Neurobiology
Chapter 4. The human brain
What exactly is a brain?
The human brain and nervous system
A brief history of what people thought of their brains
The complexity of the human brain / On really BIG numbers
Chapter 5. Some brief thoughts on pharmacology
What is pharmacology?
Psychopharmacology, plant style
Animal models in pharmacology
PART III - PLANARIANS
Chapter 6. Planarians
What is a flatworm?
Flatworm evolution and fossil records
What is a planarian?
Early works on planarians (1700-1800s)
Planariologists: Three "personal" connections
Chapter 7. Planarians in modern biology
Genetics
First they liked planarians then they didn't
Sages of regeneration
Of planarians and genomes

Chapter 8. Planarians in the popular culture: The arts, science fiction, fantasy and humor
Planarians in the popular culture
Planaria: Poem by Dr. Lance Larsen
Planarian man
Planaria and the new Battlestar Galactica
Fringe
Twilight
The Big Bang Theory
Dr. Who
Planarian humor
PART IV - THE FIRST BRAIN
Chapter 9. The first brain
Early, really early nervous systems
The first hunters
The first brain
Why are planarians an excellent animal model in neuroscience?
Very brief comments on protopsychology
Chapter 10. From corals and plants to planarians and rats
Planarians in pharmacology: nicotine and cocaine
The beginnings of systematic planarian pharmacology research
The Temple University team
The joy of discovery
From corals and plants to planarians and rats
Planarian research translated to vertebrates: What does it mean, and what it doesn't
What can the planarian brain teach us about our own?
EPILOGUE
REFERENCES - BOOKS
REFERENCES - ARTICLES

About the Author

Oné Pagán is Professor of Biology at West Chester University of Pennsylvania.

Reviews

"There are few good books about the evolution of the brain, but this is one of those few -- a journey along an ancient byway of the animal kingdom which shows just how blinkered and vertebrate-obsessed neuroscience has become. In The First Brain we learn that planarians have an array of frankly bizarre features with very real implications for the origins of our own cerebral majesty. By the end of this appealingly personal and reflective book,
Pagàn has cogently argued that it is only by studying his favorite cannibalistic worm that we can truly understand ourselves." --David Bainbridge, University Clinical Veterinary Anatomist, Cambridge University
"Flatworms are about as alien to us as an animal can be, but they finally have an ambassador. Pagan's engaging book walks us through why flatworms aren't aliens at all, and why they have the distinction of being the first animals on Earth having a "brain." ...A brain in many respects like our own." --Mark Changizi, 2ai Labs
"Reading Oné Pagán's The First Brain is a pleasure akin to sitting in the company of an especially engaging and erudite scientist as he tells of research (his own and others) on his favorite subject: in this case, the wondrous animals you and I call flatworms and biologists call planarians. Dr. Pagán's enthusiasm for science, neurobiology and the aforementioned creatures is utterly contagious. If you begin the book (like me) not
recalling exactly what a planarian is, you'll close it wondering why you and everyone you know aren't talking, thinking and writing about them all the time." --David Toomey, author of Weird Life: The Search for Life That is Very,
Very Different from Our Own
"I highly recommend this book to any clinical pediatric neurologist, neuropathologist, or basic neuroscientist with an interest in evolution and who keeps an open mind toward novel phylogenetic perspectives of the origin of the human nervous system, in addition to the novel practical research opportunities provided by this unique animal." --Journal of Child Neurology
"In this book, Professor Pagan is an engaged and excited teacher about these fascinating little worms. ... Pagan writes with prose as clear as glass, and is able to bring even centuries-old insights on flatworms into the light. --Arrow Through the Sun
"The author's enthusiasm, humor, and conversational writing style make for an enjoyable and intriguing read that should interest science enthusiasts and professionals alike. ... The First Brain is a fun and interesting work that makes a plausible case for the effective use of planarians in biomedical studies. Highly recommended." --Choice
"The inaugural brain, belonging to flatworms, is the eponymous excuse for Oné Pagán's delightful book, The First Brain..." --Peggy Mason