Table of Contents

Epidemiology and Diagnosis

1. Epidemiology

2. Disease Activity Measures

3. Disease Outcome

4. Quality of Life and Economic Aspects

Pathogenesis

1. Overview of the Pathogenesis of SLE

2. Genetics

3. Hormones

4. Immunoregulation - T Cells, B cells, and cytokines.

5. Cell Surface Receptors ostimulation/BAFF/FcgR/TLRs)

6. Dendritic Cells

7. Apoptosis

8. Structure and Origin of Autoantibodies

9. Animal Models

10. Genetics of murine lupus

11. Infection and autoimmunity

Mechanisms of Tissue Damage

1. Complement

2. Immune complexes

3. Antibodies

a. ANA and standardization of antibody techniques

b. Anti-DNA

c. Anti-splicesomosal ab

d. Anti-Ro/La

e. Anti-Histone

f. APL

g. Anti-neuronal

4. PMNs

5. Mechanisms of renal damage

6. Mechanisms of vascular damage

7. Nitric Oxide

Clinical Aspects of the Disease

1. Constitutional Symptoms and Fatigue

2. Skin

3. Kidney

4. Heart

5. Lung

6. GI/liver/pancreas

7. Infections

8. Blood (anti-phospholipid syndrome)

9. Nervous System

10. Overlap Syndromes

11. Ophthalmic Manifestations

12. Pregnancy

13. Fertility

14. Neo-natal lupus

15. Hereditary and Malignant Lupus-like Diseases

Treatment of the Disease

1. Non-Steroidals - Anti-Malarials and Statins

2. Steroid Treatment

3. Cytotoxic Drug Treatment including M.M.F

4. PAPS

5. New Treatments

About the Author

After receiving an MD from University of Athens, he came to the Arthritis Branch in 1979 where he trained in immunology and rheumatology. Between 1987 and 2007 he was a member of the Uniformed Services/Walter Reed community where served in various positions including Vice Chair for Research in the Department of Medicine and Chief of the Department of Cell Injury. In 2007 he joined the Beth Israel Medical Center as Chief of Rheumatology and Harvard Medical School as Professor of Medicine. He has served various leadership positions including President of the Clinical Immunology Society. He has served as chair of the Hypersensitivity, Autoimmunity, and Immune Mediated Diseases Study Section of the National Institutes of Health, Editor-in-Chief of Clinical Immunology, the official journal of FOCIS, and editor of Autoimmunity and Discovery Medicine, PLoS One and other journals. He has been elected to the Association of American Physicians, Fellow of the American Association for the Advancement of Sciences and Master of the American College of Physicians (MACP). He is the 2012 Lee C. Howley Jr. Arthritis Research Prize from the Arthritis Foundation and a MERIT award holder from NIH. Dr. Tsokos' research focuses on the cellular and molecular pathogenesis of systemic lupus erythematosus (SLE). His laboratory has opened and led the field of molecular abnormalities on immune cells in patients with SLE. He directs a T32-sponsored fellowship on systemic autoimmunity and a Clinical Rheumatology Fellowship. Dr. Tsokos has trained over 110 colleagues many of whom hold senior leadership positions and run independent laboratories. His research is funded through NIH and DoD grants.

Reviews

REVIEW OF THE PARENT VOLUME:
"Rejoice! The third edition of this outstanding reference work is here...Rheumatology covers all the bases and is the single text one should own if there is a limit on shelf space and budget...A remarkable accomplishment, notable for its comprehensiveness as well as its wisdom." (JAMA)