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With cutting-edge contributions from internationally recognized experts and field pioneers, Amyotrophic Lateral Sclerosis is the definitive guide to the subject. Formatted in an easily accessible manner, with summaries of key points at the end of each chapter, this guide covers all the essential information clinicians require for daily practice, as well as providing a reader-friendly approach to every aspect of ALS with detailed sections on the clinical features of disease, translational research, patient care and management, and emerging therapies.
With cutting-edge contributions from internationally recognized experts and field pioneers, Amyotrophic Lateral Sclerosis is the definitive guide to the subject. Formatted in an easily accessible manner, with summaries of key points at the end of each chapter, this guide covers all the essential information clinicians require for daily practice, as well as providing a reader-friendly approach to every aspect of ALS with detailed sections on the clinical features of disease, translational research, patient care and management, and emerging therapies.
Overview of Clinical ALS. History. Epidemiology. Pathology.
Clinical Features: Motor System. Clinical Features: Dementia and
Cognitive Deficits. Familial ALS and Genetic Approaches to ALS.
Electrophysiology and Other Objective Markers. Classification,
Diagnosis and Presentation of Diagnosis of ALS. Natural History.
Translational Research in ALS: Mechanisms behind therapy. Motor
Neuron: The origin, definition and function. Neurodegeneration.
Excitotoxicity. Oxidative Stress. Neuroinflammation.
Apoptosis. Cytoskeleton. Mitochondria. Environmental Neurotoxicity.
Genetic Causes and Predisposition. Protein Aggregate Disease.
Proteiomic and Metabolomic Approach.
Infections and Autoimmunity. Gene Transfer Technology. High
Through-put Technology. Animal Models. Restoration-Practical
Approach. Clinical Trial Methodology. ALS Therapy: Care and
Management. Multidisciplinary Approach: Ideal Care Centers and
World Perspective. Impact of National ALS Care Database and
Practice Parameters. Symptomatic Pharmacotherapy: Bulbar and
Constitutional Symptoms. Pharmacotherapy: In clinical trials.
Physical Rehabilitation. Speech Therapy and Augmentative
Communication/Assistive Technology. Nutritional treatment:
Theoretical and Practical issues. Respiratory care: Basic and
Practical. Psychosocial care: Patient and Caregiver Support.
Palliative Care. Palliative Care: Family Perspective. Decision
Making for End of Life. National ALS Study Group: Future of ALS
Clinical Research
"[This guide] illustrate[s] why this is a time of great hope in the study and treatment of ALS.Novel approaches are spelled out in excellent chapters on ALS drug screening and on genetic causes and risk factors." -Gerald D. Fischbach, Executive Vice President for Health and Biomedical Sciences and Dean of the Faculty of Medicine College of Physicians and Surgeons, Columbia University, New York, New York, U.S.A.
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