Table of Contents

Section I. Basic Concepts and Background History of Clinical Cytogenetics Steven L. Gersen DNA, Chromosomes, and Cell Division Martha B. Keagle Human Chromosome Nomenclature: An Overview and Definition of Terms Avirachan Tharapel Section II. Examining and Analyzing Chromosomes Editors' Foreword Steven L. Gersen and Martha B. Keagle Basic Laboratory Procedures Martha B. Keagle and Steven L. Gersen The Fundamentals of Microscopy Christopher McAleer Quality Control and Quality Assurance Michael Watson and Steven L. Gersen Instrumentation in the Cytogenetics Laboratory Steven L. Gersen and Lotte Downey Section III. Clinical Cytogenetics Autosomal Aneuploidy Jin-Chen C. Wang Structural Chromosome Rearrangements Kathleen Kaiser-Rogers and Kathleen Rao Sex Chromosomes and Sex Chromosome Abnormalities Cynthia M. Powell Cytogenetics of Infertility Linda Marie Randolph Prenatal Cytogenetics Linda Marie Randolph Cytogenetics of Spontaneous Abortion Solveig M. V. Pflueger Chromosome Instability Xiao-Xiang Zhang Section IV Cancer Cytogenetics Cytogenetics of Hematologic Neoplasms Rizwan C. Naeem Cytogenetics of Solid Tumors Jonathan A. Fletcher Section V. Fluorescence In Situ Hybridization Fluorescence In Situ Hybridization (FISH) Daynna J. Wolff and Stuart Schwartz Section VI. Beyond Chromosomes Editors' Foreword Steven L. Gersen and Martha B. Keagle Fragile X: From Cytogenetics to Molecular Genetics Dana C. Crawford and Patricia N. Howard-Peebles Genomic Imprinting and Uniparental Disomy Jin-Chen C. Wang Genetic Counseling Sarah Hutchings Clark Index

Reviews

From Reviews of the First Edition... "...an excellent comprehensive review of the basic concepts of clinical cytogenetics...recommended for any medical specialty that utilizes cytogenetic testing." -Modern Pathology "...a good grounding for anyone with a general interest in the subject..." -Human Genetics "...a real contribution to the field...should be a permanent resource not only for cytogeneticists, but also for doctors active in hematology and oncology, clinical pathologists, and perinatal specialists." -Laboratoriums Medezin "...an up-to-date window into the recent advances in cytogenetics, both molecular and clinical...recommended even for those who already have the first edition." - Journal of the Association of Genetic Technologists