This volume sets the stage for clinical experts working with diabetic patients as well as for researchers by describing the clinical presentations of retinopathy and their anatomical and functional correlates. It reviews currently available experimental models in animals. The impact of retinal pericytes, neuroglia and, specifically, Müller cells are discussed in detail. The volume addresses a variety of current scientific discussions about mechanisms of damage such as growth factors and the VEGF/PEDF balance in the diabetic eye, the ocular renin-angiotensin system, and leukocyte interactions with the microvasculature among others. Stem and progenitor cells in the retina are discussed as potential directions for future investigation. The final chapters return to emerging clinical aspects, including current approaches to retinopathy as a predictor of cardiovascular risk and how knowledge can be translated from bench to bedside. Bridging a widening gap in medical research between basic scientists, who may lose sight of the clinical presentations, and clinical researchers, who may grow unaware of the limits of experimental models, this volume serves as a reference platform for endocrinologists, diabetologists, ophthalmologists, as well as for scientists involved in clinical and basic research in diabetic retinopathy and other vascular complications of diabetes.
This volume sets the stage for clinical experts working with diabetic patients as well as for researchers by describing the clinical presentations of retinopathy and their anatomical and functional correlates. It reviews currently available experimental models in animals. The impact of retinal pericytes, neuroglia and, specifically, Müller cells are discussed in detail. The volume addresses a variety of current scientific discussions about mechanisms of damage such as growth factors and the VEGF/PEDF balance in the diabetic eye, the ocular renin-angiotensin system, and leukocyte interactions with the microvasculature among others. Stem and progenitor cells in the retina are discussed as potential directions for future investigation. The final chapters return to emerging clinical aspects, including current approaches to retinopathy as a predictor of cardiovascular risk and how knowledge can be translated from bench to bedside. Bridging a widening gap in medical research between basic scientists, who may lose sight of the clinical presentations, and clinical researchers, who may grow unaware of the limits of experimental models, this volume serves as a reference platform for endocrinologists, diabetologists, ophthalmologists, as well as for scientists involved in clinical and basic research in diabetic retinopathy and other vascular complications of diabetes.
Preface: Hammes, H.-P.; Porta, M.; Clinical Presentations and Pathological Correlates of Retinopathy: Bek, T.; Retinal Vascular Permeability in Health and Disease: Poulaki, V.; In vivo Models of Diabetic Retinopathy: Zheng, L.; Kern, T.S.; Pericyte Loss in the Diabetic Retina: Pfister, F.; Lin, J.; Hammes, H.-P.; Neuroglia in the Diabetic Retina: Bringmann, A.; Reichenbach, A.; Regulatory and Pathogenic Roles of Muller Glial Cells in Retinal Neovascular Processes and Their Potential for Retinal Regeneration: Limb, G.A.; Jayaram, H.; Growth Factors in the Diabetic Eye: Simo, R.; Hernandez, C.; Balance between Pigment Epithelium-Derived Factor and Vascular Endothelial Growth Factor in Diabetic Retinopathy: Ogata, N.; Tombran-Tink, J.; The Renin-Angiotensin System in the Eye: Stroder, K.; Unger, T.; Steckelings, U.M.; Interactions of Leukocytes with the Endothelium: Chavakis, T.; Stem and Progenitor Cells in the Retina: Sengupta, N.; Caballero, S.; Moldovan, N.; Grant, M.B.; Role of Pericytes in Vascular Biology: Armulik, A.; Betsholtz, C.; Current Approaches to Retinopathy as a Predictor of Cardiovascular Risk: Cheung, N.; Liew, G.; Wong, T.Y.; From Bedside to Bench and Back: Open Problems in Clinical and Basic Research: Porta, M.; Hammes, H.-P.; Author Index; Subject Index.
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